تحصیلات
- دکتری, 1375, زیست شناسی مولکولی و ژنتیک, دانشگاه آکسفورد
- کارشناسی, 1366, میکروبیولوژی, دانشگاه تهران
- کارشناسی ارشد, 1369, میکروبیولوژی, دانشگاه تهران
- فوق دکتری, 1378, مسیر پیام رسانی Wnt Signaling, دانشگاه پنسیلوانیا - آمریکا
- فوق دکتری, 1381, انکوژن ویروسی E1A, دانشگاه تکزاس آمریکا مرکز سرطان MD Anderson
مقالات چاپ شده در نشریات بینالمللی
- Bettina Diederich , Janatan F Wilkinson , T Magnin , Seyed Mahmoud Arab Najafi, Jeffery Errington , and Michaeld Yudkin . "Role of interaction between SpoIIAA and spoIIAB in regulating cell - specific transcription factor sigma F of Bacillus subtilis." Genes and Development 8, no. 21 (1994): 2653-2663.
- Seyed Mahmoud Arab Najafi, A C Willis , and Michael Dyudkin . "Site of phosphorylation of SpoIIAA, the anti - anti - sigma factor for sporulation - specific sigma F of Bacillus subtilis." JOURNAL OF BACTERIOLOGY -, no. 10 (1995): 2913-2912.
- Errington J , Feucht A , Lewis Pj , Lord M , Magnin T , Seyed Mahmoud Arab Najafi, Wilkinson Jf , and Yudkin Md . "Control of the cell-specificity of sigma F activity in Bacillus subtilis." PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 351, no. --- (1996): 542-537.
- Seyed Mahmoud Arab Najafi, David Aharris , and Michael Dyudkin . "The SpoIIAA of Bacillus subtilis has GTP - binding properties." JOURNAL OF BACTERIOLOGY 178, no. 22 (1996): 6634-6632.
- Seyed Mahmoud Arab Najafi, David Aharris , and Michael Dyudkin . "Properties of the phosphorylation reaction catalysed by spoIIAB that help to regulate sporulation of Bacillus subtilis." JOURNAL OF BACTERIOLOGY 179, no. 17 (1997): 5631-5628.
- Seyed Mahmoud Arab Najafi, Zheng Li , K Makino , R Shao , and Mc Hung . "The adenoviral E1A induces p21/CIP1 expression in cancer cells." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305, no. 4 (2003): 1104-1099.
- Seyed Mahmoud Arab Najafi. "Expression of the mouse Gaq using Baculovirus expression system." JOURNAL OF SCIENCE AND TECHNOLOGY 32, no. 1 (2006): 35-29.
- Amir Atashi , Ehsan Arefian , Jafar Kiani , Seyed Mahmoud Arab Najafi, Masoud Soleimani , and Mohammad Fallahi Sichani . "In vitro differentiation of cord blood unrestricted somatic stem cells expressing dopamine associated genes into neuron - like cells." CELL BIOLOGY INTERNATIONAL 31, no. 3 (2007): 303-299.
- Seyed Mahmoud Arab Najafi, Roghaye Mohammadzade , Esa Jahanzad , and Majid Tafrihi . "Mutations in the beta - catenin gene in gastric and esophageal cancers : an analysis in Iranian patients." Journal of Science University of Tehran 4, no. 32 (2007): 167-161.
- Eslaminejad M B , Seyed Mahmoud Arab Najafi, and Baharvand H . "Culture and Expansion of Rat Mesenchymal Stem Cells Using theSerum Prepared from Rat s Peripheral Blood." Journal of Iranian anatomical sciences 4, no. 17 (2007): 344-331.
- Eslaminejad Mb , Leyla Rouhi , Seyed Mahmoud Arab Najafi, and Hossein Baharvand . "Rat marrow - derived mesenchymal stem cell developed in a mediumsupplemented with the autologous versus bovine serum." CELL BIOLOGY INTERNATIONAL 33, no. 5 (2009): 616-607.
- Seyed Mahmoud Arab Najafi. "Activators of G proteins inhibit GSK - 3beta and stabilize beta - Catenin in Xenopus oocytes." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 382, no. 2 (2009): 365-369.
- Sara Salmanian , Seyed Mahmoud Arab Najafi, Maryam Rafipour , Maryam Rezae Arjomand , Hamideh Shahheydari , Sara Ansari , Leili Kashkooli , Sj Rasouli , Mariyeh Saghaeyan Jazi , and Tayebeh Minaei . "Regulation of GSK - 3beta and beta - Catenin by Galphaq in HEK293T cells." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 395, no. 4 (2010): 577-582.
- Elaheh Afzal , Marzieh Ebrahimi , Seyed Mahmoud Arab Najafi, Arezoo Daryadel , and Hossein Baharvand . "Potential role of heat shock proteins in neural differentiation of murine embryonal carcinoma stem cells ( P19 )." CELL BIOLOGY INTERNATIONAL 35, no. 7 (2011): 713-720.
- Majid Tafrihi, Samane Toosi, Tayebeh Minaei, Ahmad Reza Gohari, Vahid Niknam, and Seyed Mahmoud Arab Najafi. "Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells." Asian Pacific Journal of Cancer Prevention 15, no. 2 (2014): 785-791.
- Marie Saghaeian Jazi, and Seyed Mahmoud Arab Najafi. "Beta‑catenin Forms Protein Aggregation at High Concentrations in HEK293TCells." Iranian Journal of Medical Sciences 42, no. 1 (2017): 66-72.
- Narges Barati, , and Seyed Mahmoud Arab Najafi. "Membrane Localization of β-Catenin in Prostate Cancer PC3 Cells Treated with Teucrium persicum Boiss. Extract." NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 73, no. - (2021): 1-10.
- Nasim Forghani, and Seyed Mahmoud Arab Najafi. "Inhibitors of Gq signalling down-regulate β-catenin expression & function in human colon cancer cells." INDIAN JOURNAL OF MEDICAL RESEARCH 154, no. 6 (2021): 833-842.
مقالات چاپ شده در نشریات داخلی
همایشهای بینالمللی
- Seyed Mahmoud Arab Najafi. "Oral Presentation Role of interaction between spoIIAA and SpoIIAB in regulating cell-specific transcription factor sigma F of Bacillus subtilis." Iranian Society of Science and Technology, New York.
- Seyed Mahmoud Arab Najafi. "Molecular interaction between helicobacter pylori and gastric tumor." The 3rd Conference of Helicobacter pylori Group, Tehran.
- Seyed Mahmoud Arab Najafi. "Role of G-proteins in the regulation of Wnt-signal transduction." First Iranian Conference for Cell and Developmental Biology, Tehran.
- Seyed Mahmoud Arab Najafi. "Overproduction of eukaryotic proteins by using Baculovirus expression system." Iranian Biological Society Meeting, Tehran.
- Seyed Mahmoud Arab Najafi. "Expression of the mouse Gaq using Baculovirus expression system." The 3rd National Conference of Biotechnology, Mashad.
- Seyed Mahmoud Arab Najafi. "The adenoviral E1A induces p21/WAF1 expression in cancer cells." The first international congress of cancer genetics, Tehran.
- , , and Seyed Mahmoud Arab Najafi. "Rhodococcus: multi-purpose microorganism." 10th international congress for culture collection, Tsukuba.
- Seyed Mahmoud Arab Najafi, and . "Looking for mutations in exon 3 of beta-catenin gene in gastric tumor samples." The 12th Iranian Bilogy Conference, Hamedan.
- , , , Seyed Mahmoud Arab Najafi, and . "Optimization Cholestrol Oxidase production by Rhodococcus erythropolis ATCC 4277 by using Taguchi statistical method." The 4th National Biotechnology Congress, Islamic Republic of Iran, Kerman.
- Seyed Mahmoud Arab Najafi, and . "Finding some new mutations in exon 3 of beta-catenin gene in gastric tumor samples." 13th Iranian Biology Conference and the first International Conference of Biology, Rasht.
- Seyed Mahmoud Arab Najafi, and . "Looking for mutations in exon 3 of beta-catenin gene in esophageal samples." 8th Iranian Congress of Biochemistry and first International Congress of Biochemistry and Molecular Biology, Tehran.
- Seyed Mahmoud Arab Najafi, and . "Finding some new mutations in exon 3 of beta-catenin gene in gastric cancer." 8th Iranian Congress of Biochemistry and first International Congress of Biochemistry and Molecular Biology, Tehran.
- Seyed Mahmoud Arab Najafi, and . "Study of inhibition of Gq (G proteins) by a minigene encoding a C-terminal portion of the protein." 9th Iranian Genetics Congress, Tehran.
- Seyed Mahmoud Arab Najafi, and . "Investigation of the effect of plants and natural products on E-Cadherin expression." 14th National and 2nd International Conference of Biology, Tehran.
- , , Seyed Mahmoud Arab Najafi, and . "Expression of heat shock proteins during neural differentiation of Murine embryonic carcinoma stem cells." 14th conference of the international society of differentiation, Innsbruck.
- Seyed Mahmoud Arab Najafi, , and . "Study the role of Gaq on beta-Catenin expression and function by using a peptide that inhibits Gaq specifically." The Second International Congress of Cancer Genetics, Tehran.
- Seyed Mahmoud Arab Najafi. "The role of G-proteins in the regulation of Wnt-signal transduction: a pathway deregulated in many human cancers." The Second International Congress of Cancer Genetics, Tehran.
- Seyed Mahmoud Arab Najafi, and . "Regulation of Wnt-signal transduction by G-proteins: cloning and expression of a minigene encoding a peptide that blocks Gaq function." The Second International Congress of Cancer Genetics, Tehran.
- , , Seyed Mahmoud Arab Najafi, and . "The serum prepared from the rat peripheral blood significantly improves the viability and proliferation indexes of the rat mesenchymal stem cells in vitro." ?The 2nd Yazd International Student Award and Congress in reproductive Medicine, Yazd.
- , , Seyed Mahmoud Arab Najafi, and . "Heat shock and the role of heat shock proteins during neural differentiation from Murine embryonal carcinoma stem cells." The 5th ISSCR Annual Meeting, Queensland.
- , , , Seyed Mahmoud Arab Najafi, , and . "Enhancement of rat mesenchymal stem cells viability and proliferation indexes when cultured in rat serum." The 5th ISSCR annual Meeting, Queensland.
- , , Seyed Mahmoud Arab Najafi, , and . "Autologuse serum could significantly improve the viability and proliferation index of rat mesenchymal stem in vitro." The 8th Royan International Twin Congress, Tehran.
- , and Seyed Mahmoud Arab Najafi. "The role of Gaq on B-catenin expression and function." Wnt signaling in Development and disease, Berlin-Buch.
- Seyed Mahmoud Arab Najafi. "The role of Gaq on B-Catenin localization and function." The 9th Iranian Congress of Biochemistry & the 2nd International Congress of Biochemistry and Molecular Biology, Shiraz.
- , Shahrokh Safarian, , and Seyed Mahmoud Arab Najafi. "Apoptosis induction in T47D cell line in the presence of sulfabenzamide." The 9th Iranian Congress of Biochemistry & the 2nd International Congress of Biochemistry and Molecular Biology, Shiraz.
- Seyed Mahmoud Arab Najafi. "The role of Gaq on B-Catenin expression by using a peptide that inhibits Gaq specifically." The 9th Iranian Congress of Biochemistry & the 2nd International Congress of Biochemistry and Molecular Biology, Shiraz.
- , Shahrokh Safarian, , and Seyed Mahmoud Arab Najafi. "The apoptotic effect of acetazolamide on T47D cell line." The 9th Iranian Congress of Biochemistry & the 2nd International Congress of Biochemistry and Molecular Biology, Shiraz.
- Seyed Mahmoud Arab Najafi, and . "Regulation of Wnt-signal transduction by G proteins." The 1st International Congress on Health Genomics & Biotechnology, Tehran.
- , Shahrokh Safarian, , and Seyed Mahmoud Arab Najafi. "Inhibition of cell proliferation induced by sulfabenzamide through apoptosis and cell cycle arrest in T47D cell line." Apoptosis world 2008 from mrchanisms to applications,.
- , Shahrokh Safarian, , and Seyed Mahmoud Arab Najafi. "The inhibitory effects of acetazolamide on the cell proliferation:induction of apoptosis and cell cycle arrest." Apoptosis world 2008 from mechanisms to applications,.
- Seyed Mahmoud Arab Najafi, and . "Study the inhibition of Gaq on B-catenin function by measuring the expression of B-catenin target genes in HEK293 cells." 15th National & 3rd International Conference of Biology, Tehran.
- Seyed Mahmoud Arab Najafi, and . "Expression of three canonical Wnt signaling target genes in response to Gaq inhibitory peptide." 15th National 3rd International Conference of Biology, Tehran.
- Seyed Mahmoud Arab Najafi, and . "The role of Gaq on stability and cellular localization of B-catenin." 15th National & 3rd International Conference of biology, Tehran.
- , , , , and Seyed Mahmoud Arab Najafi. "Gaq activation accumulates B-catenin in HEK 293T cells." 10th Iranian Congress of Biochemistry and 3rd International Congress of Biochemistry and Molecular Biology, Tehran.
- , , , , and Seyed Mahmoud Arab Najafi. "Evaluating SW480 as a cell system to investigate the interaction between Gaq and B-catenin." 10th Iranian Congress of Biochemistry and 3rd International Congress of Biochemistry and Molecular Biology, Tehran.
- , , , Seyed Mahmoud Arab Najafi, and . "Study of interaction between Gaq and b-catenin in HT29 colon cancer." 10th Iranian Congress of Biochemistry and 3rd International Congress of Biochemistry and Molecular Biology, Tehran.
- , , , and Seyed Mahmoud Arab Najafi. "The role of herbal extracts on CDh1 (The E-cadherin encoding gene transcription in cancer cells." 12th Iranian Congress of Biochemistry 4th International Congress of Biochemistry and Molecular Biology, Mashhad.
- Seyed Mahmoud Arab Najafi, and Kolivand Sedigheh. "The role of Gaq agonists on B-catenin expression and function." 12th Iranian Congress of Biochemistry 4th International Congress of Biochemistry and Molecular Biology, Mashhad.
- , , , and Seyed Mahmoud Arab Najafi. "Investigating the expression of a few B-Catenin target genes in cells treated with Gaq agonists." 12th Iranian Genetic Congress, Tehran.
- , , and Seyed Mahmoud Arab Najafi. "The cytotoxic effects of methanolic extract of Teucrium persicum." international congress Natural anticancer drugs, Olomouc.
- Majid Tafrihi, Areza Gohari, and Seyed Mahmoud Arab Najafi. "The methanolic extract of Teucrium persicum is toxic to cancer cells." 1st Tabriz International Life Science conference, 12th Iran Biophysical Chemistry Conference, Tabriz.
- Eghbal Jasemi, Mostafa Zamani, and Seyed Mahmoud Arab Najafi. "The role of two Gq agonists (Thrombin and Carbachol) on cellular b-Catenin protein levels and b-Catenin-target gene expression in HT-29 colon cancer cells." 1st Tabriz International Life Science conference, 12th Iran Biophysical Chemistry Conference, Tabriz.
- Marie Saghaeian, Sedigheh Kolivand, and Seyed Mahmoud Arab Najafi. "Study on interaction between Gq and B-Catenin signaling pathways in HEK-293T cells." 1st Tabriz International Life Science conference, 12th Iran Biophysical Chemistry Conference, Tabriz.
- Seyed Mahmoud Arab Najafi. "The Gaq class of Ga proteins positively regulates Wnt/B-Catenin signal transduction." The 2nd International GI Cancer Congress, Tehran.
- Ashkan Veysi, Eghbal Jasemi, Nazanin Ahmadi, and Seyed Mahmoud Arab Najafi. "Investigation of Gaq agonists on B-Catenin target gene expression and cellular B-Catenin protein levels in Colon cancer cell line." 2nd International and 14th Iranian Genetics Congress, Tehran.
- Seyed Mahmoud Arab Najafi. "Deregulation of Wnt signal transduction in Human cancer." 2nd IASBS Symposium in Biological Sciences: Cancer Cell Biology, zanjan.
- Leyli Naraghi, Nasrin Motamed, and Seyed Mahmoud Arab Najafi. "The effect of endogenous Gaq activation on expression of some B-catenin target genes in SW480 cells." 3rd International Gastrointestinal Cancer Congress, Tehran.
- Seyed Mahmoud Arab Najafi. "Regulation of wnt signal transduction by hetrotrimeric G-proteins." 3rd International Nastaran Cancer Symposium 2017, Mashhad.
- Nasim Forghani, and Seyed Mahmoud Arab Najafi. "Regulation of β-Catenin signaling by Gq class of G-proteins in colon cancer cells." 4th International GI Cancer Congress, Tehran.
- Nahid Khosronezhad, and Seyed Mahmoud Arab Najafi. "The role of Gαq signaling on β-Catenin expression in HEK293T cells." 4th International GI Cancer Congress, Tehran.
- Ghazal Arjmand, and Seyed Mahmoud Arab Najafi. "Antibiotics as anti-cancer agents." The 5Th INTERNATIONAL CONGRESS ON BIOMEDICINE,.
- Seyed Mahmoud Arab Najafi. "Targeting Wnt signaling in controlling human cancers." 22nd National and 10th international Congress on Biology, Shahrekord.
- Ghazal Arjmand Kermani, and Seyed Mahmoud Arab Najafi. "The role of Gαq activity on the cellular localization of β-catenin protein: A better understanding of EMT molecular mechanism." 5th International and 17th Iranian Genetics Congress, Tehran.
- Zahra Abrehdari-tafreshi, Ehsan Arefian, and Seyed Mahmoud Arab Najafi. "Evaluation of driver mutations in EGFR and KRAS in non-small cell lung cancer and the correlation with program death ligand-1 expression in Iranian patients." CSMBFORUM2023, Valencia.
- Fatemeh Eslamizadeh, Ehsan Farashahi Yazd, and Seyed Mahmoud Arab Najafi. "Targeted Therapy in Retinoblastoma: Promise and Progress." The First International Congress of Cancer Genomics (CGC2023), Tehran.
- Seyed danial Hashemi, Hossein Azizi, and Seyed Mahmoud Arab Najafi. "Differential cytoskeleton protein genes expression analysis between human sperm of patients with non-obstructive azoospermia and normal." 3rd International Conference on Modern Technologies in Sciences, Amol.
- نسیم فرقانی، مریم رفیع پور و سیدمحمود عرب نجفی. "مثالی از کاربرد مینی ژن ها در بیان پپتید های کنترل کننده مسیرهای پیام رسانی در سلول." چهارمین همایش بینالمللی و دوازدهمین کنگره ملی بیوتکنولوژی جمهوری اسلامی ایران، تهران.
- سعید موسوی و سیدمحمود عرب نجفی. "انالیز بیوانفورماتیکی نواحی پروموتری ژنهای اختصاصی بافت کولون شامل CDX2 و CLCA1 و MS4A12." بیست و دومین کنگره ملی و دهمین کنگره بین المللی زیست شناسی ایران، شهرکرد.